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CAS Number: 1062159-35-6
while free MMAE (0
Calabrò S
InChi: InChI=1S/C22H32N6
KU-0063794 Catalog No.:M7746-2 CAS Number: 1062159-35-6KU 0063794 is a potent and selective mTOT inhibitor, which inhibits both mTORC1 and mTORC2 with an IC50 of approximately 10 nM, but does not suppress the activity of 76 other protein kinases or seven lipid kinases, including Class 1 PI3Ks (phosphoinositide 3 kinases) at 1000 fold higher concentrations. KU 0063794 is cell permeant, suppresses activation and hydrophobic motif phosphorylation of Akt, S6K and SGK, but not RSK (ribosomal S6 kinase), an AGC
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