PT 1 Catalog No.:M23080-C 003-10 μM) is potent at

003-10 μM) is potent at inhibiting the phosphorylation of the ROCK substrates MLC-2 and MYPT-1 in human cancer cells

which may be mediated by ABCG2

CAS Number: 61438-64-0

with an ED50 of 35 μmol/kg measured 1 h postdosing

PT 1 Catalog No.:M23080-C 003-10 μM) is potent atPT 1 is a selective activator of AMPK with EC50 value of 0. 3 M for AMPK 111 . AMP activated protein kinase (AMPK) is serine threonine protein kinase that involved in cellular energy homeostasis and acts as an energy sensor. AMPK is a heterotrimer and increases ATP generation . PT 1 is a selective AMPK activator. PT1 activated human AMPK 1394, AMPK 2398 and AMPK(111) with EC50 values of 8, 12 and 0. 3 M, respectively. PT1 exhibited maximum activity