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1007/s40265-017-0816-z
and also limited connective tissue ingrowth
5-dioxo-1-((6-(5-((3aS
which is a concentration that has little or no adverse effect on the host cell (cell viability >80%)
GV-58 60427 1007/s40265-017-0816-zGV 58 is a potent, selective N and P Q type Ca2+ channels agonist with EC50 of 7. 21 8. 81 uM for N type P Q type Ca2+ channel; 20 fold less potent CDK inhibitor activity. IC50 value: 7. 21 8. 81 uM (N type P Q type Ca2+ channel) Target: Ca2+ channel agonistIn comparison with the parent molecule, (R) roscovitine, GV 58 has a 20 fold less potent cyclin dependent kinase antagonist effect, a 3 to 4 fold more potent Ca2+ channel agonist effect, and 4 fold
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