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PubMed PMID: 26219952
31)28-13-12-17(15-28)6-11-23(29)26-22-5-3-2-4-21(22)24
potent and selective G-protein coupled receptor kinase 2 and 3 (GRK2/GRK3) inhibitor (IC50 values are 35 and 32 nM at GRK2 and GRK3 respectively)
The MDL29951-activated receptor exhibits other activities associated with GPCR-mediated signaling
TAS-301 - CAS# 193620-69-8 002euronal-LSB3i PubMed PMID: 26219952TAS 301, CAS No. 193620 69 8, is a potent and selective constrictive remodeling regulator on renarrowing after balloon overstretch injury of porcine coronary artery. TAS 103 inhibits smooth muscle cell migration and proliferation. TAS 103 inhibits intimal thickening after balloon injury to rat carotid arteries. TAS 301 blocks receptor operated calcium influx and inhibits rat vascular smooth muscle cell proliferation induced by basic fibroblast growth