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Ilginatinib maleate (NS-018 maleate) (12
CAS Number: 161735-79-1
but it is highly cleared in rat liver microsome (RLM) with ER of 0
98 μM in surface plasmon resonance (SPR) assay
PF-03715455 524evizinone Ilginatinib maleate (NS-018 maleate) (12PF 03715455 is a potent inhaled p38 MAPK inhibitor. PF 03715455 shows some selectivity for p38 over p38 with respective IC50 values of 0. 88 and 23 nM. PF 03715455 potently inhibits LPS induced TNF production in human whole blood (IC50=1. 7 nM). PF 03715455 has potential for the treatment of COPD (chronic obstructive pulmonary disease). Product information CAS Number: 1056164 52 3 Molecular Weight: 700. 27 Formula: C35H34ClN7O3S2 Chemical Name: 3 [3