Agomelatine-d4 - CAS# 1079389-44-8 Catalog No.:M34906-C InChi: InChI=1S/C36H62O31/c37-1-12-18(44)24(50)25(51)31(61-12)67-36(30(56)23(49)17(6-42)66-36)11-60-35(29(55)22(48)16(5-41)65-35)10-59-34(28(54)21(47)15(4-40)64-34)9-58-33(27(53)20(46)14(3-39)63-33)8-57-32(7-43)26(52)19(45)13(2-38)62-32/h12-31

InChi: InChI=1S/C36H62O31/c37-1-12-18(44)24(50)25(51)31(61-12)67-36(30(56)23(49)17(6-42)66-36)11-60-35(29(55)22(48)16(5-41)65-35)10-59-34(28(54)21(47)15(4-40)64-34)9-58-33(27(53)20(46)14(3-39)63-33)8-57-32(7-43)26(52)19(45)13(2-38)62-32/h12-31

22-15+/t28-/m1/s1/i19D

and also greatly suppresses the stimulated IκB-α phosphorylation and degradation in HCECs

Smiles: C/C=C(/C)\C(=O)O[C@@H]1C[C@@]2(C)O[C@@H]2C[C@H](OC(C)=O)C(C)=C[C@H]2OC(=O)C(=C)[C@H]12

Agomelatine-d4 - CAS# 1079389-44-8 Catalog No.:M34906-C InChi: InChI=1S/C36H62O31/c37-1-12-18(44)24(50)25(51)31(61-12)67-36(30(56)23(49)17(6-42)66-36)11-60-35(29(55)22(48)16(5-41)65-35)10-59-34(28(54)21(47)15(4-40)64-34)9-58-33(27(53)20(46)14(3-39)63-33)8-57-32(7-43)26(52)19(45)13(2-38)62-32/h12-31Agomelatine d4 is the deuterium labeled Agomelatine. Agomelatine (S 20098) is a specific agonist of MT1 and MT2 receptors with Kis of 0. 1, 0. 06, 0. 12, and 0. 27 nM for CHO hMT1, HEK hMT1, CHO hMT2, and HEK hMT2, respectively. Agomelatine is a selective 5 HT2C receptor antagonist with pKis of 6. 4 and 6. 2 at native (porcine) and cloned, human 5 HT2C receptors, respectively. Product information CAS Number: 1079389 44 8 Molecular Weight: 247. 33