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12 epoxides by CYP4A2 and CYP4A3 enzymes
3-dioxygenase pathway controls complement-dependent enhancement of chemo-radiation therapy against murine glioblastoma
Chemical Name: 1-(2-{4-[5-chloro-1-(4-fluorophenyl)-1H-indol-3-yl]piperidin-1-yl}ethyl)imidazolidin-2-one
InChi: InChI=1S/C22H22O4/c1-26-20-13-17(8-5-15-3-2-4-19(24)11-15)21(22(25)14-20)12-16-6-9-18(23)10-7-16/h2-4
Gnetol C 16590 12 epoxides by CYP4A2 andGnetol is a phenolic compound isolated from the root of Gnetum ula Brongn. Gnetol potently inhibits COX 1 (IC50 of 0. 78 M) and HDAC. Gnetol is a potent tyrosinase inhibitor with an IC50 of 4. 5 M for murine tyrosinase and suppresses melanin biosynthesis. Gnetol has antioxidant, antiproliferative, anticancer and hepatoprotective activity. Gnetol also possesses concentration dependent Amylase, glucosidase, and adipogenesis activities. Product
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