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pii: S0031-9384(16)30416-4
Smiles: CC1=CNC(C=C2C3=CC=CC=C3NC2=O)=C1CCC(O)=O
IWR-1 inhibits epithelial-mesenchymal transition of colorectal cancer cells through suppressing Wnt/β-catenin signaling as well as survivin expression
PubMed PMID: 12511611
MERcK-5 - CAS# 457081-03-7 Catalog No.:M6539-2 pii: S0031-9384(16)30416-4Pyridone 6, also known CMP 6 or JAK Inhibitor I, CAS No. 457081 03 7, is a pan Janus activated kinase inhibitor, Pyridone 6 interferes with JAK kinase activity by interacting within the ATP binding cleft. It inhibits JAK1, 2, and 3 with IC50 values of 15, 1, and 5 nM, respectively. Pyridone 6 suppresses osteoclast formation and bone resorption through down regulation of receptor activator of nuclear factor kappaB (NF kappaB) ligand (RANKL) induced c
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