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B-Raf IN 1 (Compound 10n) inhibits WM 266-4 and HT29 cells with IC50s of 0
equivalent to levels observed in small hairpin RNA knockdown of G9a and GLP
Madrasin stalls spliceosome assembly at the A complex
Formula: C27H31N7OS
AGN-193931 6-2005 B-Raf IN 1 (Compound 10n)AGN 195183 is a potent and selective agonist of RAR(Kd=3 nM) with improved binding selectivity relative to AGN 193836; no activity on RAR . IC50 value: 3 nM (Kd); 200 nM (EC80, RAR Trans.) Compound 4(AGN 195183) inhibited the growth of breast cancer cell lines, and was inactive in an in vivo model of topical irritation. Compound 4 and ATRA inhibit growth of the human breast cancer cell lines, T 47D and SK BR 3, compound 4 does not cause the topical
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