YKL-5-124 TFA Catalog No.:M14492-2 and non-toxic natural product may

and non-toxic natural product may finds its application in the antibacterial drug development for treating multidrug-resistant Gram negative infections

Van Dongen M

UNC6852 selectively degrades EED and EZH2

UCB1184197

YKL-5-124 TFA Catalog No.:M14492-2 and non-toxic natural product mayYKL 5 124 TFA is a potent, selective, irreversible and covalent CDK7 inhibitor with IC50s of 53. 5 nM and 9. 7 nM for CDK7 and CDK7 Mat1 CycH, respectively. YKL 5 124 TFA is >100 fold greater selective for CDK7 than CDK9 and CDK2, and inactive against CDK12 and CDK13. YKL 5 124 TFA induces a strong cell cycle arrest, inhibits E2F driven gene expression, and exhibits little effect on RNA polymerase II phosphorylation status. Product information