Midostaurin - CAS# 120685-11-2 60268 which inhibited the release of

which inhibited the release of TNF-alpha by lipopolysaccharide (a monocyte stimulus)-treated human peripheral blood mononuclear cells with an IC(50) of 3 nM

5 to 5 micromol/L (similar to that of decitabine)

InChiKey: CBIAWPMZSFFRGN-UHFFFAOYSA-N

Int J Neuropsychopharmacol

Midostaurin - CAS# 120685-11-2 60268 which inhibited the release ofMidostaurin, CAS No. 120685 11 2, also known as PKC 412, PKC 412A and CGP 41251; is a synthetic indolocarbazole multikinase inhibitor with potential antiangiogenic and antineoplastic activities. Midostaurin inhibits protein kinase C alpha (PKCalpha), vascular endothelial growth factor receptor 2 (VEGFR2), c kit, platelet derived growth factor receptor (PDGFR) and FMS like tyrosine kinase 3 (FLT3) tyrosine kinases, which may result in disruption of the