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NSC 669364
InChi: InChI=1S/C28H27N7O2/c1-35(2)17-5-9-26(36)31-24-8-3-6-20(18-24)27(37)32-22-10-12-23(13-11-22)33-28-30-16-14-25(34-28)21-7-4-15-29-19-21/h3-16
Stimulation of alpha-adrenergic receptors causes vasoconstriction of the radial smooth muscle of the iris
the MTT assay is performed
VX-661 Catalog No.:M10067-10 NSC 669364Tezacaftor, also known asVX 661, is CFTR modulator. VX 661 is potentially useful for treatment of cystic fibrosis disease. Cystic fibrosis (CF) is a genetic disease caused by defects in the CF transmembrane regulator (CFTR) gene, which encodes an epithelial chloride channel. The most common mutation, 508CFTR, produces a protein that is misfolded and does not reach the cell membrane. VX 661 can correct trafficking of 508CFTR and partially restore