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AZD-9291 demonstrates improved rat PK
but not other RORs
BHPI is a potent noncompetitive ERα biomodulator
Treatment with RS-1 promoted significant antitumor responses in a mouse model
AT-406 nbolone acetate AZD-9291 demonstrates improved rat PKDeBio 1143, also known as AT 406, ARRY 334543and SM 406, is an orally bioavailable inhibitor of IAP (Inhibitor of Apoptosis Protein) family of proteins with potential apoptotic inducing and antineoplastic activity. AT 406 selectively inhibits the biological activity of IAP proteins, including X chromosome linked IAP (XIAP), the cellular IAPs 1 (c IAP1) and 2 (c IAP2) and melanoma inhibitor of apoptosis protein (ML IAP). This may restore and promote