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CAS Number: 88768-40-5
Mustophorane
InChi: InChI=1S/C17H20ClN3O3
and in steroid-resistant nephrotic syndrome
EPZ004777 - DOT1L inhibitor. CAS# 1338466-77-5 ionamide CAS Number: 88768-40-5EPZ004777 is a potent, selective inhibitor of DOT1L. Treatment of mixed lineage leukemia (MLL) cells with EPZ004777 selectively inhibits H3K79 methylation and blocks expression of leukemogenic genes. Exposure of leukemic cells to EPZ004777 results in selective killing of those cells bearing the MLL gene translocation, with little effect on non MLL translocated cells. Finally, in vivo administration of EPZ004777 leads to extension of survival in a
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