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ARD-266 12896 PubMed PMID: 24019254

SKU: 10049017526

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Description

PubMed PMID: 24019254

Chemical Name: (2E)-1-(pyridin-4-yl)-3-(quinolin-2-yl)prop-2-en-1-one

4-difluorophenyl)propan-2-yl]-5-chloro-4-(4-chloro-1-methyl-1H-pyrazol-5-yl)furan-2-carboxamide hydrochloride

3]thiazol-6-yl)phenyl]naphthalene-2-carboxamide

ARD-266 12896 PubMed PMID: 24019254ARD 266 is a highly potent and VHL E3 ligase based androgen receptor (AR) PROTAC degrader. ARD 266 effectively induces degradation of AR protein in AR positive LNCaP, VCaP, and 22Rv1 prostate cancer cell lines with DC50 values of 0. 2 1 nM. Product information Molecular Weight: 915. 51 Formula: C52H59ClN6O7 Chemical Name: (2S,4R) 4 hydroxy 1 [(2R) 3 methyl 2 (3 methyl 1,2 oxazol 5 yl)butanoyl] N [(1S) 3 oxo 1 phenyl 3 {4 [2 (4 {[(1r,3r) 3 (3 chloro 4

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