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Abstract 1045
InChiKey: JRIBPWOXWIRQOQ-GHAIFCDISA-N
RS-127445 potently antagonizes 5-HT-evoked formation of inositol phosphates (pKB=9
As a similar increase in [3H]spiperone binding is found with a variety of agents which increase the synaptic concentration of endogenous DA
AR-A 2 12952 Abstract 1045AR A 2 is a selective 5 HT1B receptor antagonist, with high affinity to guinea pig cortex 5HT1B 1D and recombinant guinea pig 5 HT1B receptors (Ki=0. 24 and 0. 47 nM) and with 10 fold lower affinity to guinea pig 5 HT1D receptor (Ki, 5 nM), and shows an EC50 of 4. 5 nM for the guinea pig 5 HT1B receptor; AR A 2 can be used in the research of depression and anxiety. Product information CAS Number: 220051 79 6 Molecular Weight: 448. 60 Formula: