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This Generation 2 Legendary beast sparks waves of nostalgia for collectors, so its no surprise to see it earn a spot on the list

Nyla, Shirshu Sleuth's second ability has an "intervening 'if' clause." That means the ability won't trigger at all unless you control no Clues at the beginning of your end step, and the ability will do nothing if you control a Clue by the time it resolves

You have a growing win condition of Commander Damage, you get to draw cards, and you have an alternate win condition in burn to each opponent

This discounts all your creatures, all while becoming a terrifying threat once it starts mutating frequently