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It shuts down activated abilitiesthink planeswalkers, fetch lands, or combo pieceswithout needing to target anything

That could be typical aristocrat synergies like Blood Artist and Midnight Reaper or cards like Serra Paragon and Lurrus of the Dream-Den that can recast the Cleric

Nadus sheer power comes from the fact that you can target it with free stuff like equipment that cost 0 to equip and draw a bunch of cards, and you can do this twice per turn for each creature you control

Seat of the Synod is the king of the colored lands, because blue is the color that works best with artifacts, and Vault of Whispers is second because of Disciple of the Vault, but all of them have joined the fun at one point or another